| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes |
| L1 | Survey of Clinical Cases of Biomaterials-Tissue Interactions | |
| L2 | Tissue Structures, Unit Cell Processes, and Integrins | Homework 1 due |
| L3 | Unit Cell Processes Comprising the Healing Response | |
| L4 | Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs | Homework 2 due |
| L5 | Biochemistry of the ECM | Homework 3 due |
| L6 | Scaffolds Based on ECM Analogs Used in Organ Synthesis | |
| L7 | Organ Replacement by Induced Regeneration and Tissue Engineering | |
| L8 | Principles and Practice of Tissue Engineering | Homework 4 due |
| E1 | Quiz 1 | |
| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue |
| L9 | Characteristics of the Surfaces of Biomaterials | |
| L10 | Methodology for the Analysis of Surfaces | |
| L11 | Physicochemical Principles of Protein Adsorption on Solid Surfaces | Homework 5 due |
| L12 | Protein/Cell/Tissue-Biomaterials Interactions | Homework 6 due |
| L13 | Linear vs. Cooperative Cell-Matrix Interactions | Homework 7 due |
| L14 | Cell-Matrix Interactions During Spontaneous Healing | |
| L15 | Contraction-Blocking Theory of Regeneration in Adults | |
| E2 | Quiz 2 | |
| III. In Vivo and Clinical Case Studies |
| L16 | Joints and Dental Tissues: Prosthetic Replacement | |
| L17 | Joints and Dental Tissues: Regeneration 1 | |
| L18 | Joints and Dental Tissues: Regeneration 2 | |
| L19 | Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses | |
| L20 | Rules for Synthesis of Tissues and Organs | |
| L21 | In Vivo Synthesis of Skin | Homework 8 due |
| L22 | In Vivo Synthesis of Peripheral Nerves | |
| L23 | In Vivo Synthesis of the Conjunctiva and of Kidney Tissue | |
| E3 | Quiz 3 | |