Jobs:

Job No.

• Job Title:
• Postdoctoral Associate
• Employer:
• Baylor College of Medicine
• Location:
• Houston, TX
• Posting Date:
• 10-Oct-2025
• Apply
• Description:

• Summary

  We are seeking a highly motivated Postdoctoral Fellow to join our interdisciplinary research team investigating the genetic drivers of Inflammatory Bowel Disease (IBD). This position offers an exciting opportunity to work on a cutting-edge, NIH-funded project that combines high-throughput genetic screening in C. elegans with human intestinal organoid validation to understand how genetic risk factors contribute to IBD pathogenesis. The successful candidate will contribute to a comprehensive study titled “High-throughput functional analyses of the genetic drivers of Inflammatory Bowel Disease.”

  Job Duties

  • Primary Research Activities:
    • Designs and executes high-throughput RNAi screens of IBD risk genes in C. elegans.
    • Performs phenotypic analyses including bacterial colonization assays, motility measurements, and barrier integrity assessments.
    • Generates and characterizes CRISPR-edited C. elegans strains modeling human IBD risk alleles.
    • Collaborates on human intestinal organoid studies including genetic modifications and functional characterizations.
    • Conducts transcriptional profiling and pathway analyses to understand gene function.
  • Technical Skills Development:
    • Masters advanced C. elegans genetics techniques including CRISPR/Cas9 genome editing.
    • Gains expertise in microbiome manipulation and high-throughput screening methods.
    • Learns human organoid culture, genetic modification, and functional assays.
    • Develops bioinformatics skills for analyzing genomic and transcriptomic datasets.
  • Collaborative Opportunities:
    • Works closely with human geneticists, gastroenterologists, and organoid biologists.
    • Participates in analyses of diverse population genetic data through IBDGC collaborations.
    • Contributes to translational studies bridging model organism findings to human disease.

  Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.

  Preferred Qualifications

  • PhD in Genetics, Cell Biology, Molecular Biology, or related field
  • Strong background in at least one of the following areas:
    • C. elegans genetics and molecular biology
    • Human cell culture and organoid systems
    • Microbiome research
    • Inflammatory disease mechanisms
  • Experience with molecular cloning, CRISPR/Cas9, or RNAi techniques
  • Proficiency in quantitative data analysis and statistical methods
  • Excellent written and verbal communication skills
  • Ability to work independently and collaboratively in a team environment
  • Previous experience with C. elegans or other model organisms
  • Background in gastrointestinal biology or inflammatory diseases
  • Familiarity with high-throughput screening approaches
  • Experience with organoid culture systems
  • Knowledge of bioinformatics tools and programming (R, Python)
  • Track record of peer-reviewed publications

  Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

• Apply

•  Contact information:
• Baylor College of Medicine