Las Vegas is ranked number 1 as the most stressful citities in America due to the highest percentage of unemployment rate and generally people are living in an unhealthy way.( not sure if it's due to people's temptation on gambling habits). Second is Los Angeles, ranked number 7 on the unemployment rate list. Third is Houston, mainly due to unemployment rate is below nation's average but people are workaholics and work very long hours which leads to unhealthy lives.